EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST EXPERIMENTAL POLIOMYELITIS
نویسندگان
چکیده
منابع مشابه
Experiments on Active Immunization against Experimental Poliomyelitis
The results obtained in this investigation indicate that poliomyelitis virus treated with tannin, sodium ricinoleate, or formalin does not constitute a satisfactory immunizing agent in monkeys against the experimental disease.
متن کاملActive Immunization against Poliomyelitis
1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.
متن کاملActive Immunization against Poliomyelitis in Monkeys
1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, ...
متن کاملActive immunization of hamsters against experimental infection with Borrelia burgdorferi.
The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccination. Animals were sacrificed 14 days after challenge, and the kidneys and spleen...
متن کاملIntradermal versus Subcutaneous Immunization of Monkeys against Poliomyelitis
1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar virus material. 2. The degree of protection conferred by intradermal is greater than by subcutaneous injection. 3. During intradermal and subcutaneous inoculations, no local or general pathological s...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1936
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.63.1.109